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My main research interests are centered around the effects of helminth infections on the immune system. Schistosomiasis and intestinal dwelling nematodes are amongst the most common infections of man and approximately one in three of the world's population harbours at least one species and most infections are in low income countries. Helminth infections are recognized as one of the world’s most important causes of physical and intellectual growth retardation in children. An understanding of helminth-induced immune activation is essential for the development of vaccines that can stimulate protective immunity while avoiding pathological consequences. The main focus of my work is to increase our understanding of mechanisms of immune regulation and resistance and how chronic worm infections may alter immune responses to unrelated infections.